Sameh Abdelwahed
Assistant Professor
Advanced Medicinal & Supramolecular Chemistry (AMSC) Lab.
College of Arts & Sciences,
College of Arts & Sciences,
Welcome to the AMSC Lab!
Our research focuses on the design and synthesis of biologically active heterocyclic organic compounds and the synthesis and study of charge delocalization mechanisms in molecular wires.
Enzyme Catalysis and Radical Intermediates
Investigating the mechanisms of enzyme-catalyzed reactions, particularly those involving radical intermediates, to understand their role in essential biosynthetic pathways like thiamin and vitamin B12 production. This includes exploring the evolutionary significance and impact on enzyme function in metabolic regulation.
Antiviral Drug Development
Exploring medicinal plants for antiviral properties, particularly against SARS-CoV-2. This involves computational virtual screening to identify potential herbal-based modulators for developing novel antiviral treatments.
Cancer Therapy and Drug Development
Developing targeted anticancer therapies by designing and optimizing quinazoline-based and quinoxaline-based compounds. This includes focusing on protein kinase inhibitors and PARP-1 inhibitors to create safer, more effective treatments with high selectivity and low toxicity.
AMSC Lab. Facilities
Recent News
Team of AMSC Lab. Presenting their collaborative work at the CISR 2024 Conference
From left to right: Sophia, Taylor, Jennifer, and Caleb. They attended the CISR 2024 Conference to present their collaborative work on thiamin and cancer therapy.
Recent Publications
Exploring the Role of TRANSKETOLASE LIKE-1 (TKTL-1) in Cancer: Insights into Oncogenic Metabolism and Therapeutic Prospects
Ahmad Junaid, Joel Caleb Nwaogwugwu, and Sameh Abdelwahed. Cancer Informatics. Accepted and under publication, 2024.
Supporting grant from Prairie View University, Faculty Research Development Grant Program (FRDGP).
New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-inflammatory, DNA Gyrase B Inhibition and In Silico Studies
Somaia S. Abd El-Karima, Manal M. Anwara, Yasmin M. Syama, Hassan M. Awad, Asmaa Negm El-Dein, Mohamed K. El-Ashrey, and Sameh Abdelwahed. Preprints 2024, 2024081792, under publication.
https://doi.org/10.20944/preprints202408.1792.v1
Design, Synthesis, and Antimicrobial Evaluation of Some New Thiopyrimidin-Benzenesulfonamide Compounds
Abdalrahman Khalifa, Manal M. Anwar, Walaa A. Alshareef, Eman Abd Elaziz El Gebaly, Samia A. Elseginy, and Sameh Abdelwahed. Preprints 2024, 2024081943. Under publication. https://doi.org/10.20944/preprints202408.1943.v1
Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis
Vishav Sharma, Dmytro Fedoseyenko, Sumedh Joshi, Sameh Abdelwahed, and Tadhg P. Begley. ACS Central Science, 2024.
Supporting grant from the National Institutes of Health (DK44083) and by the Robert A. Welch Foundation (A0034).
Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)
Heba T. Abdel-Mohsen, Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim and Sameh H. Abdelwahed. Molecules, 2024.
Funded by the Robert A. Welch Foundation, grant number L-0002, and Prairie View University Faculty, grant number 552509-00018.
Design, Synthesis, Electronic Properties, and X-ray Structural Characterization of Various Modified Electron-Rich Calixarene Derivatives and Their Conversion to Stable Cation Radical Salts
Rajendra Rathore, Sergey V. Lindeman, and Sameh H. Abdelwahed. Molecules, 2023.
Funded by the Robert A. Welch Foundation, grant number L-0002, and Prairie View University Faculty, grant number 552509-00018.
Contact
Assistant Prof. Sameh Abdelwahed.
Prairie View A&M University
Department of Chemistry
Prairie View, TX 77446, P.O. Box 519, MS 2215
Email: shabdelwahed@pvamu.edu