Welcome to the AMSC Lab!
Our research focuses on the design and synthesis of biologically active heterocyclic organic compounds and the synthesis and study of charge delocalization mechanisms in molecular wires.
Investigating the mechanisms of enzyme-catalyzed reactions, particularly those involving radical intermediates, to understand their role in essential biosynthetic pathways like thiamin and vitamin B12 production. This includes exploring the evolutionary significance and impact on enzyme function in metabolic regulation.
Exploring medicinal plants for antiviral properties, particularly against SARS-CoV-2. This involves computational virtual screening to identify potential herbal-based modulators for developing novel antiviral treatments.
Developing targeted anticancer therapies by designing and optimizing quinazoline-based and quinoxaline-based compounds. This includes focusing on protein kinase inhibitors and PARP-1 inhibitors to create safer, more effective treatments with high selectivity and low toxicity.
Recent News
From left to right: Sophia, Taylor, Jennifer, and Caleb. They attended the CISR 2024 Conference to present their collaborative work on thiamin and cancer therapy.
Recent Publications
Ahmad Junaid, Joel Caleb Nwaogwugwu, and Sameh Abdelwahed. Cancer Informatics. Accepted and under publication, 2024.
Supporting grant from Prairie View University, Faculty Research Development Grant Program (FRDGP).
Somaia S. Abd El-Karima, Manal M. Anwara, Yasmin M. Syama, Hassan M. Awad, Asmaa Negm El-Dein, Mohamed K. El-Ashrey, and Sameh Abdelwahed. Preprints 2024, 2024081792, under publication.
https://doi.org/10.20944/preprints202408.1792.v1
Abdalrahman Khalifa, Manal M. Anwar, Walaa A. Alshareef, Eman Abd Elaziz El Gebaly, Samia A. Elseginy, and Sameh Abdelwahed. Preprints 2024, 2024081943. Under publication. https://doi.org/10.20944/preprints202408.1943.v1
Vishav Sharma, Dmytro Fedoseyenko, Sumedh Joshi, Sameh Abdelwahed, and Tadhg P. Begley. ACS Central Science, 2024.
Supporting grant from the National Institutes of Health (DK44083) and by the Robert A. Welch Foundation (A0034).
Heba T. Abdel-Mohsen, Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim and Sameh H. Abdelwahed. Molecules, 2024.
Funded by the Robert A. Welch Foundation, grant number L-0002, and Prairie View University Faculty, grant number 552509-00018.
Rajendra Rathore, Sergey V. Lindeman, and Sameh H. Abdelwahed. Molecules, 2023.
Funded by the Robert A. Welch Foundation, grant number L-0002, and Prairie View University Faculty, grant number 552509-00018.
Assistant Prof. Sameh Abdelwahed.
Prairie View A&M University
Department of Chemistry
Prairie View, TX 77446, P.O. Box 519, MS 2215
Email: shabdelwahed@pvamu.edu
